BOYLE (ROBERT) The Sceptical Chymist: or Chymico-Physical Doubts & Paradoxes, touching the Spagyrist's Principles commonly call'd Hypostatical, as they are wont to be Propos'd and Defended by the Generality of Alchymists, FIRST EDITION, J. Cadwell, for J. Crooke, 1661

The Sceptical Chymist was published in 1661. It is the first book to combine chemistry with physics and paved the way for the work of Isaac Newton and, 200 years later, Antoine Lavoisier. In it, Boyle postulated the then revolutionary theory that matter was composed of atoms and clusters of atoms in motion and that every phenomenon was the result of the collision of particles in motion. He also explored the relationship between chemicals through the use of theory and experiments rather than largely through observation.

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