LEDERBERG, JOSHUA and EDWARD L. TATUM.
1. "Novel genotypes in mixed cultures of biochemical mutants of bacteria." Offprint from: Cold Spring Harbor Symposia on Quantitative Biology 11, 1946. 8vo. 113-114 pp.
2."Gene recombination in the bacterium Escherichia coli." Offprint from: Journal of Bacteriology 53, 1947. 673-684 pp.
3. ---, and NORTON D. ZINDER. "Genetic exchange in salmonella." Offprint from: Journal of Bacteriology 64, 1952. 679-699 pp, plus mimeographed addenda sheet.
8vo. Item 1 in original printed wrappers, creased horizontally, margins a bit sunned. Items 2 and 3 without wrappers, light dust-soiling. The three bound together in blue library cloth with 27 other offprints by Lederberg, plus 1 offprint laid in, and 1 paper by Lederberg's wife Esther Lederberg. A complete listing of titles is available upon request.
Provenance: Lederberg's address label tipped to first page of item 2; Ex-Libris of G.and E. Meynell Biology Lab, University of Kent with initials stamped to spine; Jeremy Norman.
FIRST SEPARATE EDITIONS OF THE PAPERS WHICH CONTAINED THE WORK FOR WHICH LEDERBERG WAS JOINTLY AWARDED THE 1958 NOBEL PRIZE, AND FIRST SEPARATE EDITION OF THE PAPER WHICH INTRODUCES HIS DISCOVERY OF TRANSDUCTION. Lederberg shared the 1958 Nobel Prize for physiology or medicine with Tatum and George Beadle for their essential contributions to bacterial genetics. Among these contributions was Lederberg and Tatum's discovery of sexual processes in the reproduction of certain strains of E. coli bacteria, which they first announced at the July 1946 symposium at Cold Spring Harbor in their paper "Novel genotypes in mixed cultures of biochemical mutants of bacteria." "Gene recombination in the bacterium Escherichia coli," their first complete paper on bacterial sexual reproduction, was published the following year. Lederberg left Yale in 1947 for the University of Wisconsin, where he founded and chaired that university's Department of Medical Genetics. During his tenure at Wisconsin he continued his studies in bacterial genetic recombination, collaborating with his wife, Esther Lederberg, and several other research associates. With one of these, his former student Norton Zinder, Lederberg discovered another means of introducing new genetic material into bacteria: the process of transduction, in which small fragments of hereditary material are transferred from one bacterium to another through the action of a bacterial virus. Lederberg and Zinder's discovery was published in their 1952 paper, "Genetic exchange in salmonella." Garrison-Morton 255.4 (item 2); Garrison-Morton 256.1 (item 3).